the best 'buddy' movie

Have you seen Planes, Trains and Automobiles? To see even the last 15 or 20 minutes of it is to witness greatness! I dunno bout u, but seeing big fat John Candy being such a sad sad lonely man pulls at my heartstrings. I wonder how he ranked his performance in this film - was it a personal best, or am I thinking too much and it was just 'meh...', anyhoo...